Created: 2021-01-27 Wed 10:24
| Frank Jülicher | The Barnes/Drubin Lab | Tyler Harmon |
Ideas for complementary experiments?
| 2D phase separation can induce GUV tubulation | autophagosome growth deforms target condensate through wetting |
| strong enrichment of likely phase-separating proteins | liquid-like network of early proteins required for mammalian endocytosis |
| Side view | Top view |
membrane tension
\(\sigma\left(S_{0}+S_{m}+S_{i}\right)\)
bending energy
\(\frac{K}{2} S_{i}\left(\frac{2}{R_{i}}-2 C_{i}\right)^{2}\)
combined membrane tension and bending energy
\(F=\sigma\left(S_{0}+S_{m}+S_{i}\right)+\frac{K}{2} S_{i}\left(\frac{2}{R_{i}}-2 C_{i}\right)^{2}\)
surface tension
\(\gamma_{d} S_{d}\)
wetting energy (note: negative contribution!)
\(\gamma_{m} S_{m}+\gamma_{i} S_{i}\)
combined surface tension and wetting energy
\(F=\gamma_{d} S_{d}-\gamma_{m} S_{m}-\gamma_{i} S_{i}\)
\(P V_{i}\)
\(F=\sigma\left(S_{0}+S_{m}+S_{i}\right)+\frac{K}{2} S_{i}\left(\frac{2}{R_{i}}-2 C_{i}\right)^{2}+\gamma_{d} S_{d}-\gamma_{m} S_{m}-\gamma_{i} S_{i}+P V_{i}\)
| boundary diagram | free energy plot |
| volume = 107 nm3 | volume = 109 nm3 |